http://www.sciencedaily.com/releases/2010/08/100811125943.htm  What is needed is muscle fatigue.  A big heavy weight will do it in a few lifts, a lighter weight will do it a bit later, but both will do the same thing.  
And for the elderly that can't handle it: 
http://www.sciencedaily.com/releases/2010/05/100514151926.htm reducing blood flow makes light weights feel heavier, which allows a workout with less weight.  
 
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